Arie Zask Selected Research

HTI-286

5/2005	Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin.
10/2004	Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
11/2003	Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules.
4/2003	HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

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Arie Zask Research Topics

Disease

21	Neoplasms (Cancer) 01/2017 - 04/2003
2	Macular Degeneration (Age-Related Maculopathy) 01/2020 - 03/2013
2	Breast Neoplasms (Breast Cancer) 10/2016 - 10/2004
2	Glioma (Gliomas) 01/2010 - 05/2005
2	Osteoarthritis 06/2003 - 06/2003
1	COVID-19 01/2022
1	Alzheimer Disease (Alzheimer's Disease) 09/2015
1	Obesity 05/2013
1	Hypoxia (Hypoxemia) 01/2010
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2005
1	Renal Cell Carcinoma (Grawitz Tumor) 05/2005
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2004
1	Arthritis (Polyarthritis) 06/2003
1	Cardiovascular Diseases (Cardiovascular Disease) 06/2003
1	Multiple Sclerosis 06/2003
1	Neoplasm Metastasis (Metastasis) 06/2003
1	Carcinoma (Carcinomatosis) 04/2003

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 01/2017 - 10/2004
4	Mechanistic Target of Rapamycin Complex 1IBA 10/2016 - 08/2009
4	Sirolimus (Rapamycin)FDA Link 10/2016 - 08/2009
4	Phosphotransferases (Kinase)IBA 10/2016 - 08/2009
4	TOR Serine-Threonine KinasesIBA 07/2011 - 08/2009
4	HTI-286IBA 05/2005 - 04/2003
3	Pharmaceutical PreparationsIBA 01/2022 - 10/2004
3	Biological ProductsIBA 01/2020 - 07/2011
3	Mechanistic Target of Rapamycin Complex 2IBA 10/2016 - 08/2009
3	Antineoplastic Agents (Antineoplastics)IBA 09/2015 - 05/2005
3	MTOR InhibitorsIBA 07/2011 - 08/2009
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2010 - 02/2006
3	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 05/2005 - 04/2003
3	Paclitaxel (Taxol)FDA LinkGeneric 05/2005 - 04/2003
2	EnzymesIBA 09/2015 - 06/2003
2	Biomarkers (Surrogate Marker)IBA 02/2010 - 01/2010
2	Bevacizumab (Avastin)FDA Link 01/2010 - 01/2010
2	AcidsIBA 06/2003 - 06/2003
2	Matrix Metalloproteinase InhibitorsIBA 06/2003 - 06/2003
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 01/2022
1	DNA AdductsIBA 01/2020
1	PhytoalexinsIBA 01/2020
1	Antisickling AgentsIBA 01/2020
1	DiterpenesIBA 01/2020
1	Hormones (Hormone)IBA 01/2020
1	brevetoxinIBA 01/2020
1	TriterpenesIBA 01/2020
1	VanadiumIBA 01/2020
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2020
1	celastrol methyl esterIBA 01/2020
1	GinkgolidesIBA 01/2020
1	Cyclin D1IBA 10/2016
1	etomoxirIBA 10/2016
1	phenanthriplatinIBA 09/2015
1	Propranolol (Inderal)FDA LinkGeneric 09/2015
1	DNA (Deoxyribonucleic Acid)IBA 09/2015
1	GuanineIBA 09/2015
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2015
1	LigandsIBA 09/2015
1	Analgesics (Analgesic Drugs)IBA 09/2015
1	Amyloid (Amyloid Fibrils)IBA 09/2015
1	Cisplatin (Platino)FDA LinkGeneric 09/2015
1	phenazine FDA Link 09/2015
1	Glycoproteins (Glycoprotein)IBA 09/2015
1	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA 05/2013
1	Cyclooxygenase 1IBA 05/2013
1	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 05/2013
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 05/2013
1	TachykininsIBA 05/2013
1	AntioxidantsIBA 03/2013
1	Adenosine Triphosphate (ATP)IBA 07/2011
1	Protein Kinases (Protein Kinase)IBA 07/2011
1	morpholineIBA 02/2010
1	WYE 125132IBA 01/2010
1	temsirolimus FDA Link 01/2010
1	WYE-354IBA 08/2009
1	17-hydroxywortmanninIBA 02/2006
1	WortmanninIBA 02/2006
1	hemiasterlinIBA 05/2005
1	pegylated 17-hydroxywortmanninIBA 05/2005
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2005
1	multidrug resistance-associated protein 1IBA 10/2004
1	HTI 042IBA 09/2004
1	Vincristine (Oncovin)FDA LinkGeneric 04/2003

Therapy/Procedure

7	Therapeutics 01/2022 - 02/2008
4	Drug Therapy (Chemotherapy) 01/2010 - 05/2005
1	Oral Administration 01/2010
1	Intravenous Injections 05/2005